I am watching my husband play as we speak. I agree with Jynx, its not as scary/creepy as the first one, but thats probably because we've seen the splicers and other crazy bastards, so its not creepy anymore.
Big Sisters are definitely a new scare, though, because they're constantly screaming! It gets in my head! zohmug!
On a funny note, my husband's friend can't play this game because he has crippling hydrophobia. That made me laugh. *bad person*